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But he died eight months later just short of his seventh birthday.
This tumor impacts only 300 to 400 children a year in the United States - making Ocean Springs' rare surge in cases highly unusual.
Sophia went through radiation, oral chemotherapy and clinical trial drugs in an attempt to stop the progression of the disease.
Sophia Mohler (left) and Jaxon Schoenberg (right) were the first two children from Ocean Springs, Mississippi, who were diagnosed with DIPG.
It forms in the glial tissue, which is responsible for supporting and protecting the brain's neurons.
Radiation can briefly halt the spread of the tumor for an average of six to nine months, but there is no cure.
Before she was diagnosed, Sophia loved to dance and be active.